Our understanding of the physiological systems that regulate food intake and body weight
has increased immensely over the past decade. Brain centres, including the hypothalamus …

In addition to digesting and assimilating nutrients, the intestine and associated visceral
organs play a key sensing and signaling role in the physiology of energy homeostasis. The …

Despite dramatic fluctuations in calorie intake, animals maintain a very stable body weight.
The reason is that energy intake and expenditure are precisely matched. Long-term …

This study investigated the effect of subcutaneously administered oxyntomodulin on body
weight in healthy overweight and obese volunteers. Participants self-administered saline or …

Our knowledge of the physiological systems controlling energy homeostasis has increased
dramatically over the last decade. The roles of peripheral signals from adipose tissue …

Peptide YY (PYY) and glucagon like peptide (GLP)-1 are cosecreted from intestinal L cells,
and plasma levels of both hormones rise after a meal. Peripheral administration of PYY3–36 …

The actions of the structurally related proglucagon-derived peptides (PGDPs)—glucagon,
glucagon-like peptide (GLP)-1 and GLP-2—are focused on complementary aspects of …

Pharmacotherapy for the management of obesity is primarily aimed at weight loss, weight
loss maintenance and risk reduction, and has included thyroid hormone, amphetamines …

Aims/hypothesis Long-term trials in insulin-treated subjects with type 2 diabetes have shown
that adjunctive treatment with the amylin analogue pramlintide reduces HbA 1 c levels and …

Ghrelin, an acylated peptide produced predominantly by the stomach, has been discovered
to be a natural ligand of the growth hormone secretagogue receptor type 1a (GHS‐R1a) …