Viruses that establish long‐term infections in their hosts have evolved a number of methods
to interfere with the activities of the innate and adaptive immune systems. Control of viral …

Background Severe acute respiratory syndrome (SARS) emerged in later February 2003, as
a new epidemic form of life-threatening infection caused by a novel coronavirus. However …

When hepatitis B virus (HBV)-specific CD8+ cytotoxic T lymphocytes (CTLs) are adoptively
transferred into HBV transgenic mice, they enter the liver, recognize antigen, secrete …

The acquisition of effector functions by naive CD8 T cells following TCR engagement is
thought to occur sequentially with full functionality being gained only after the initiation of …

We developed a new class of vaccines, based on killed but metabolically active (KBMA)
bacteria, that simultaneously takes advantage of the potency of live vaccines and the safety …

It is believed that CD8+ T lymphocytes or Abs can independently clear many primary viral
infections, including those caused by Orthopoxviruses (OPV), a genus that includes the …

We previously observed a loss of Epstein-Barr virus (EBV)–specific CD8+ T cells in subjects
progressing to EBV-related non-Hodgkin lymphoma (NHL), correlating with loss of CD4+ T …

Five pediatric patients with no history of immunodeficiency had a life-threatening course of
varicella. Strikingly, natural killer (NK) cells were absent from the circulation in all children …

The failure of HIV-specific CD8+ T cells to control HIV has suggested a functional defect for
these cells in HIV infection. Recently, HIV-specific CD8+ T cells from HIV-infected patients …

CD8 T cells have been shown to play an important role in the clearance and protection
against fatal Ebola virus infection. In this study, we examined the mechanisms by which CD8 …