Our understanding of the physiological systems that regulate food intake and body weight
has increased immensely over the past decade. Brain centres, including the hypothalamus …

Until relatively recently, the small number of identifiable inherited human diseases
associated with marked obesity were complex, pleiotropic developmental disorders, the …

The increasing incidence of obesity in developed nations is an ever-growing challenge to
health care, promoting diabetes and other diseases. The hormone leptin, which is derived …

Leptin is an adipocyte‐derived hormone that acts as a major regulator for food intake and
energy homeostasis. Leptin deficiency or resistance can result in profound obesity, diabetes …

Our knowledge of the physiological systems controlling energy homeostasis has increased
dramatically over the last decade. The roles of peripheral signals from adipose tissue …

Leptin is an adipocyte-secreted hormone that plays a key part in energy homoeostasis.
Advances in leptin physiology have established that the main role of this hormone is to …

The adipose tissue-derived hormone leptin regulates energy balance and neuroendocrine
function. Resistance to the appetite-suppressing effects of leptin is associated with common …

Ectopic fat accumulation has been implicated as a contributing factor in the abnormal
metabolic state of obesity. One human model of ectopic fat deposition is generalized …

Genetic factors are involved in the regulation of body weight and in determining individual
responses to environmental factors such as diet and exercise. The identification and …

Regulated energy homeostasis is fundamental for maintaining life. Unfortunately, this critical
process is affected in a high number of mentally ill patients. Eating disorders such as …