The sensation commonly referred to as 'pain'has two components. The first is the sensory-
discriminative component and provides information on location, modality and intensity of …

Opiates lack potent analgesic efficacy in neuropathic pain although it is now generally
accepted that the poor effect of these drugs reflects a reduction in their potency. Reduction of …

A deficit of endogenous pain inhibitory systems has been suggested to contribute to some
chronic pain conditions, one of them being fibromyalgia. The aim of the investigation was to …

The present study examined the interactive effects of state and trait anxiety on pain threshold
and subjective pain intensity. State anxiety was manipulated in 15 low trait anxious (LTA) …

A method for measuring indices of brain activity includes non-invasively obtaining signals of
central nervous system (CNS) activity, localizing signals to specific anatomical and …

Although research on DNIC has revealed the inhibitory effect occurring between two remote
pain stimuli, the interrelation between two adjacent painful stimuli has not yet been …

The midbrain periaqueductal gray (PAG) and ventromedial medulla (VMM) are generally
viewed as the core of an endogenous descending modulatory system. However, available …

The affective and the sensory dimensions of pain processing can be differentiated in
humans through the use of questionnaires and verbal communication. It is difficult to …

Clinical experience supports the use of antidepressant medications to treat chronic pain
syndromes, such as low back pain and fibromyalgia. Although this use of antidepressants is …

In this paper we1 assess the potential for research on nonhuman animals to address
questions about the phenomenology of painful experiences. Nociception, the basic capacity …