In order to overcome multidrug resistance in solid tumors, doxorubicin (DOX) loaded pH-
sensitive micelles of which surface was decorated with folate (PHSM/f) were evaluated both …

To endow enhanced tumor specificity and endosome disruption property on the carrier, a
multifunctional polymeric micelle was investigated. The micelle exposes the cell interacting …

pH-Responsive drug carriers have the potential to provide selective drug release at
therapeutic targets including tumors and in acidic intracellular vesicles such as endosomes …

Objective We investigate microscopic pH heterogeneity within tumor spheroids using a
novel 1 H NMR methodology that provides high resolution measurements of intraspheroidal …

The critical role of pH status in physiology and pathophysiology of living organisms is well
recognized. This includes local acidosis induced by ischemia, infection or inflammation …

In the last two decades, the development of polymers which change their structures and
properties in response to environmental stimuli such as pH, temperature, and light has …

Cancer is a complex disease exhibiting a host of phenotypic diversities. Noninvasive
multinuclear magnetic resonance imaging (MRI) and spectroscopic imaging (MRSI) provide …

A multisample magnetic resonance imaging (MRI) method was used to measure the effects
of a range of paramagnetic metal ions and chelating ligands on the T1 and T2 values of the …

We report the synthesis of a new family of chelating ligands containing bispyrazole structure.
Some of them undergo an unusual reactivity when they react with methyl iminodiacetate. We …

In the last two decades, the development of polymers which change their structures and
properties in response to environmental stimuli such as pH, temperature, and light has …