Many neurodegenerative disorders are characterized by conformational changes in proteins
that result in misfolding, aggregation and intra-or extra-neuronal accumulation of amyloid …

Spinal and bulbar muscular atrophy (SBMA) is an adult-onset motor neuron disease caused
by the expansion of a trinucleotide CAG repeat encoding the polyglutamine tract in the first …

As key molecular chaperone proteins, heat shock proteins (HSPs) represent an important
cellular protective mechanism against neuronal cell death in various models of neurological …

The heat shock protein (HSP) molecular chaperones are the primary cellular defense
against damage to the proteome, initiating refolding of denatured proteins and regulating …

The dependence of developing spinal motoneuron survival on a soluble factor (s) from their
target, muscle tissue is well established both in vivo and in vitro. Considering this apparent …

Early events in Alzheimer's disease (AD) pathogenesis implicate the accumulation of β-
amyloid (Aβ) peptide inside neurons in vulnerable brain regions. However, little is known …

More than 100 different mutations in the gene encoding Cu, Zn-superoxide dismutase
(SOD1) cause preferential motor neuron degeneration in familial amyotrophic lateral …

Dysfunction of the ubiquitin‐dependent protein degradation system, either at the level of the
proteasome itself, or at the level of ubiquitination, may play a role in the pathogenesis of …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by
progressive motor neuron degeneration, paralysis, and death. Mutant Cu, Zn-superoxide …

Small heat shock proteins (small HSPs) are molecular chaperones that protect cells against
stress by assisting in the correct folding of denatured proteins and thus prevent aggregation …