Life is the interplay between structure and energy, yet the role of energy deficiency in human
disease has been poorly explored by modern medicine. Since the mitochondria use …

There is significant evidence that the pathogenesis of several neurodegenerative diseases,
including Parkinson's disease, Alzheimer's disease, Friedreich's ataxia (FRDA), multiple …

In studies of Alzheimer's disease pathogenesis there is an increasing focus on mechanisms
of intracellular amyloid-β (Aβ) generation and toxicity. Here we investigated the inhibitory …

Intracellular amyloid beta-peptide (Aβ) accumulation is considered to be a key pathogenic
factor in sporadic Alzheimer's disease (AD), but the mechanisms by which it triggers …

This article aims to give a broad overview of some of the potential targets for nitric oxide
(NO) in the brain. The relevance of NO in both physiological and pathological scenarios is …

Ginkgo biloba extract EGb 761 has been used for many years to treat age‐related cognitive
disorders including Alzheimer's disease. EGb 761 given shortly after initiating mitochondrial …

In order to clarify the basis of neuronal toxicity exerted by the shortest active peptides of
amyloid beta-protein (Aβ), the toxic effects of Aβ (31–35) and Aβ (25–35) peptides on …

Objective: To determine if stavudine (α4T)-associated mitochondrial toxicity could be
reversed by substitution with another nucleoside reverse transcriptase inhibitor. As …

Stroke and neurodegenerative disease exert an increasing large toll on human health at the
levels both of the individual and of society. As an example of each, in the United States …

Apoptosis may be initiated in neurons via mitochondrial release of the respiratory protein,
cytochrome c. The mechanism of cytochrome c release has been studied extensively, but …