The fetal brain is protected from the effects of acute hypoxia by a range of haemodynamic
and metabolic compensations. Hypoxia alone is therefore an unusual cause of perinatal …

The possibility of a therapeutic role for cerebral hypothermia during or after resuscitation
from perinatal asphyxia has been a long-standing focus of research. However, early studies …

In the fetal lamb model of hypoxic–ischaemic injury, the insult is followed by EEG
depression, after which seizures emerge at 7–13 hours. We explored the relationship …

Résumé Les événements qui surviennent avant l'accouchement et qui sont tenus pour
responsables de la naissance d'un enfant présentant une déficience physique ou mentale …

The fetal brain develops rapidly during the last trimester of pregnancy. Therefore, the brain
of infants who are born preterm is vulnerable to changes in oxygen and nutrient supply in …

Background: Sufficient O2 supply to the brain is necessary for adequate cerebral energy
metabolism, function and growth. Objectives: To elucidate the relation between changes in …

Intrauterine growth restriction and infection are significant risk factors for neonatal hypoxic
ischaemic encephalopathy in term neonates. It was hypothesised that these two factors …

Background: Although intrapartum hypoxia-ischaemia is an important cause of death and
permanent brain injury, current available methods for the detection of damaging fetal …

Moderate to severe hypoxic-ischemic encephalopathy continues to be an important cause of
acute neurologic injury at birth, occurring in approximately 1 to 2 cases per 1000 term live …

This thesis describes the effects of hypoxemia and hypotension on brain cell function and
brain metabolism in the near-term born lamb. Electrocortical brain activity (ECBA), which …