Data analysis plays an indispensable role for understanding various phenomena. Cluster
analysis, primitive exploration with little or no prior knowledge, consists of research …

Repbase Update is a comprehensive database of repetitive elements from diverse
eukaryotic organisms. Currently, it contains over 3600 annotated sequences representing …

We predict regulatory targets of vertebrate microRNAs (miRNAs) by identifying mRNAs with
conserved complementarity to the seed (nucleotides 2–7) of the miRNA. An …

Here we report a high-quality draft genome sequence of the domestic dog (Canis familiaris),
together with a dense map of single nucleotide polymorphisms (SNPs) across breeds. The …

Transfer RNAs (tRNAs) and small nucleolar RNAs (snoRNAs) are two of the largest classes
of non-protein-coding RNAs. Conventional gene finders that detect protein-coding genes do …

Genome-wide expression profiling is a powerful tool for implicating novel gene ensembles
in cellular mechanisms of health and disease. The most popular platform for genome-wide …

Motivation: Promoter analysis is an essential step on the way to identify regulatory networks.
A prerequisite for successful promoter analysis is the prediction of potential transcription …

The hypothesis that the relatively large and complex vertebrate genome was created by two
ancient, whole genome duplications has been hotly debated, but remains unresolved. We …

Cytosine methylation is required for mammalian development and is often perturbed in
human cancer. To determine how this epigenetic modification is distributed in the genomes …

Metabolomics, in particular gas chromatography–mass spectrometry (GC–MS) based
metabolite profiling of biological extracts, is rapidly becoming one of the cornerstones of …