The variety of diseases caused by mutations in RET receptor tyrosine kinase provides a
classic example of phenotypic heterogeneity. Gain-of-function mutations of RET are …

To improve our ability to identify hematopoietic stem cells (HSCs) and their localization in
vivo, we compared the gene expression profiles of highly purified HSCs and non-self …

Hereditary origin of a tumor helps toward early discovery of its mutated gene; for example, it
supports the compilation of a DNA panel from index cases to identify that gene by finding …

Single nucleotide polymorphisms (SNPs) of the coding regions of receptor tyrosine kinase
gene (RET) are associated with Hirschsprung's disease (HSCR, aganglionic megacolon) …

Most tissues are patterned so that progenitors in different locations are programmed to have
different properties. Stem cells from different regions of the nervous system acquire intrinsic …

Neural crest cells that originate in the caudal hindbrain migrate into and along the
developing gastrointestinal tract to form the enteric nervous system. While they are …

Glial cell line-derived neurotrophic factor (GDNF)/Ret signaling is required for enteric neural
crest survival, proliferation, migration and process extension, but signaling pathways that …

In the vertebrate embryo, the neural crest cells (NCCs) that migrate out from the neural
primordium yield multiple phenotypes, including melanocytes, peripheral neurones and glia …

Enteric nervous system : Current Opinion in Gastroenterology Enteric nervous system : Current
Opinion in Gastroenterology Log in or Register Subscribe to journalSubscribe Get new issue …

There is enormous excitement about the potential of transplanted neural stem or progenitor
cells to replace CNS neurons and glial cells lost through injury (eg, spinal cord injury) or …