There is a large body of literature showing that prolactin (PRL) exerts growth-promoting
activities in breast cancer, and possibly in prostate cancer and prostate hyperplasia. In …

Growth hormone is believed to activate the growth hormone receptor (GHR) by dimerizing
two identical receptor subunits, leading to activation of JAK2 kinase associated with the …

Covalent attachment of poly (ethylene glycol)(PEG) molecules to drugs, proteins, and
liposomes is a proven technology for improving their bioavailability, safety, and efficacy …

Acromegaly is associated with insulin resistance and an increased incidence of
cardiovascular disease. However, it remains unclear to what extent the effects of growth …

Sex differences in hepatic drug metabolism have been known for more than 30 years, based
on the early studies of Kato, Conney, Gillette, and others^~^. In rats and certain other …

This book reviews the pathophysiology and physical manifestations of acromegaly and
discusses the multiple treatment options now available for the management of the patient …

Acromegaly is a chronic debilitating disorder caused by a growth hormone (GH)-producing
pituitary adenoma. Active acromegaly is associated with a two-to fourfold increased mortality …

There is an increasing number of patients with diabetes mellitus in many countries. Diabetic
kidney disease, one of its microvascular complications, is also increasing markedly and has …

outside the plasma membrane (Wang et al. 2002). Based on the sequence similarity of the
rabbit and human GHRs in the extracellular stem region, it appears likely that the human …