Adipokines: molecular links between obesity and atheroslcerosis

DCW Lau, B Dhillon, H Yan… - American Journal of …, 2005 - journals.physiology.org
Atherosclerotic disease remains the leading cause of death in industrialized nations despite
major advances in its diagnosis, treatment, and prevention. The increasing epidemic of …

The relationship between inflammation and venous thrombosis

EA Fox, SR Kahn - Thrombosis and haemostasis, 2005 - thieme-connect.com
During the past decade, the role of inflammation in the pathophysiology of arterial
thrombosis has been elucidated. However, comparatively little is known about the …

C-reactive protein in heart failure: prognostic value and the effect of valsartan

IS Anand, R Latini, VG Florea, MA Kuskowski… - Circulation, 2005 - Am Heart Assoc
Background—The role of C-reactive protein (CRP) in heart failure is not well studied. We
assessed the prognostic value of CRP in patients randomized in Val-HeFT (Valsartan Heart …

Statins reduce interleukin-6–induced C-reactive protein in human hepatocytes: new evidence for direct antiinflammatory effects of statins

C Arnaud, F Burger, S Steffens… - … , and vascular biology, 2005 - Am Heart Assoc
Objectives—Besides its predictive role in determining cardiovascular risk, C-reactive protein
(CRP) may exert direct proatherogenic effects through proinflammatory properties. CRP is …

Inflammation and carotid artery—risk for atherosclerosis study (ICARAS)

M Schillinger, M Exner, W Mlekusch, S Sabeti… - Circulation, 2005 - Am Heart Assoc
Background—Compelling evidence suggests that inflammation is fundamentally involved in
the pathogenesis of atherosclerosis; however, temporal correlation between inflammation …

C-reactive protein comes of age

S Verma, PE Szmitko, PM Ridker - Nature Clinical Practice …, 2005 - nature.com
Cardiovascular disease remains a leading cause of death throughout the world despite
advances in its detection and treatment. Commonly used risk algorithms, such as the …

Thematic review series: the immune system and atherogenesis. Lipoprotein-associated inflammatory proteins: markers or mediators of cardiovascular disease?

A Chait, CY Han, JF Oram, JW Heinecke - Journal of lipid research, 2005 - ASBMB
In humans, a chronically increased circulating level of C-reactive protein (CRP), a positive
acute-phase reactant, is an independent risk factor for cardiovascular disease. This …

Inflammation and endothelial function: direct vascular effects of human C-reactive protein on nitric oxide bioavailability

BR Clapp, GM Hirschfield, C Storry, JR Gallimore… - Circulation, 2005 - Am Heart Assoc
Background—Circulating concentrations of the sensitive inflammatory marker C-reactive
protein (CRP) predict future cardiovascular events, and CRP is elevated during sepsis and …

Loss of pentameric symmetry in C-reactive protein induces interleukin-8 secretion through peroxynitrite signaling in human neutrophils

T Khreiss, L József, LA Potempa, JG Filep - Circulation research, 2005 - Am Heart Assoc
Plasma levels of C-reactive protein (CRP), nitrotyrosine, and interleukin-8 (IL-8) are known
predictors of acute cardiovascular events. Peroxynitrite (ONOO−) may function as an …

C-reactive protein–induced in vitro endothelial cell activation is an artefact caused by azide and lipopolysaccharide

KE Taylor, JC Giddings… - … , and Vascular Biology, 2005 - Am Heart Assoc
Objective—C-reactive protein (CRP) has been proposed to be an independent risk factor for
cardiovascular disease. In vitro studies investigating the mechanism behind this have used …