Zebrafish as a model vertebrate for investigating chemical toxicity

AJ Hill, H Teraoka, W Heideman… - Toxicological …, 2005 - academic.oup.com
Zebrafish (Danio rerio) has been a prominent model vertebrate in a variety of biological
disciplines. Substantial information gathered from developmental and genetic research …

Effect of dispersant on the composition of the water‐accommodated fraction of crude oil and its toxicity to larval marine fish

CM Couillard, K Lee, B Légaré… - … and Chemistry: An …, 2005 - Wiley Online Library
Newly hatched mummichog (Fundulus heteroclitus) were exposed in a 96‐h static renewal
assay to water‐accommodated fractions of dispersed crude oil (DWAF) or crude oil (WAF) to …

Acute toxicity of diazinon on the common carp (Cyprinus carpio L.) embryos and larvae

R Aydın, K Köprücü - Pesticide biochemistry and physiology, 2005 - Elsevier
In the present study, the toxic effects on the embryos and larvae of the common carp were
used as a model to investigate the organophosphorus pesticide, diazinon, which …

Treatment of mice with 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin leads to aryl hydrocarbon receptor-dependent nuclear translocation of NF-κB and expression of Fas …

IA Camacho, N Singh, VL Hegde… - The Journal of …, 2005 - journals.aai.org
We investigated the role of aryl hydrocarbon receptor (AhR) in the regulation of 2, 3, 7, 8-
tetrachlorodibenzo-p-dioxin (TCDD)-induced apoptosis in thymic T cells. AhR knockout (KO) …

Cardiovascular gene expression profiles of dioxin exposure in zebrafish embryos

HM Handley-Goldstone, MW Grow… - Toxicological …, 2005 - academic.oup.com
Abstract 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (TCDD) is a widespread environmental
contaminant that causes altered heart morphology, circulatory impairment, edema …

Inhibition of neovascularization by environmental agents

I Ivnitski-Steele, MK Walker - Cardiovascular toxicology, 2005 - Springer
The formation of new blood vessels, neovascularization, occurs by two unique processes:
vasculogenesis, the de novo assembly of blood vessels from angioblast precursors, and …

Targeted knockdown of insulin-like growth factor binding protein-2 disrupts cardiovascular development in zebrafish embryos

AW Wood, PJ Schlueter, C Duan - Molecular endocrinology, 2005 - academic.oup.com
Abstract IGF binding protein-2 (IGFBP-2) is an evolutionarily conserved protein that binds
IGFs and modulates their biological activities. Although the actions of IGFBP-2 have been …

The aryl hydrocarbon receptor predisposes hepatocytes to Fas-mediated apoptosis

KT Park, KA Mitchell, G Huang, CJ Elferink - Molecular pharmacology, 2005 - ASPET
Liver homeostasis is achieved by the removal of diseased and damaged hepatocytes and
their coordinated replacement to maintain a constant liver cell mass. Cirrhosis, viral …

Interactions between lipids and persistent organic pollutants in fish

AA Elskus, TK Collier, E Monosson - Biochemistry and molecular biology of …, 2005 - Elsevier
Publisher Summary This chapter highlights the importance of tissue-lipid composition, the
disposition of persistent organic pollutants, and persistent organic pollutants (POPs) effects …

2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) Induces Organ- Specific Differential Gene Expression in Male Japanese Medaka (Oryzias latipes)

DC Volz, DC Bencic, DE Hinton, JMH Law… - Toxicological …, 2005 - academic.oup.com
Abstract 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (TCDD) is a ubiquitous environmental
contaminant with well-known adverse effects in fish. In this study, we initially exploited …