Human mesenchymal stem cells (hMSCs) expanded with and without fibroblast growth
factor (FGF) supplementation were compared with respect to their proliferation rate, ability to …

We present a novel indentation method for characterizing the viscoelastic properties of
alginate and agarose hydrogel based constructs, which are often used as a model system of …

Cartilage tissue engineering relies on in vitro expansion of primary chondrocytes. Monolayer
is the chosen culture model for chondrocyte expansion because in this system the …

Our previous study indicated that interleukin (IL)-1β induces expression of several Wnt
proteins in chondrocytes and causes chondrocyte dedifferentiation via the c-Jun/activator …

Accumulation of β-catenin and subsequent stimulation of β-catenin-T cell-factor
(Tcf)/lymphoid-enhancerfactor (Lef) transcriptional activity causes dedifferentiation of …

OBJECTIVE: Many genetically modified animal models are providing new keys for unlocking
the pathophysiology of cartilage degradation. To produce a tool for cellular and molecular …

OBJECTIVE: The higher incidence of osteoarthritis in females suggests that there may be
intrinsic sex-specific differences in human articular chondrocytes. 17β-Estradiol (E2) …

To evaluate the degree of cellular dedifferentiation, subculture of chondrocytes was
conducted on a surface coated with collagen type I at a density of 1.05 mg/cm2. In the …

Interleukin (IL)-1β is a major catabolic pro-inflammatory cytokine involved in cartilage
destruction-associated processes, such as loss of the differentiated chondrocyte phenotype …

Biomechanical forces are major epigenetic factors that determine the form and differentiation
of skeletal tissues, and may be transduced through cell adhesion to the intracellular …