Hypertension is a multifactorial disease involving complex interactions between genetic and
environmental factors. Development of experimental models of hypertension allowed …

The objectives of this project were two-fold: to identify the genetic mutation that has been
detected as an MboI dimorphism in intron 9 of the human renin (REN) gene and to confirm a …

Despite excellent antihypertensive drugs on the market, about 70% of all hypertensive
patients do not have their blood pressure under control. This is due to problems of …

Objective. We recently reported on a missense mutation in exon 9 of the human renin gene
(G1051A) that may affect the functioning of this enzyme, and is associated with essential …

Antisense therapeutics can be applied to hypertension. Hypertension is a widespread
disease, yet in spite of several excellent drugs for the treatment of hypertension, the number …

Hypertension is a polygenic and multifactorial disease and is intimately related to salt
homeostasis. Four important vasoactive peptide systems participate in regulating blood …

Genetic approaches such as gene targeting have been extensively used to gain a better
understanding of the role of hormones and pathways involved in cardiovascular physiology …

Genetic approaches such as gene targeting have been extensively used to gain a better
understanding of the role of hormones and pathways involved in cardiovascular physiology …

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