Since their initial discovery in yeast, cyclin-dependent kinases have proven to be universal
regulators of the cell cycle in all eukaryotes. In unicellular eukaryotes, cell cycle progression …

In recent years, we have witnessed major advances in our understanding of the mammalian
cell cycle and how it is regulated. Normal mammalian cellular proliferation is tightly …

Cdc45 is required for initiation of DNA replication and fork progression, but its function in
these processes remains unknown. We show that targeting Cdc45 to specific chromosomal …

Development of acquired resistance to antiestrogens is a major clinical problem in
endocrine treatment of breast cancer patients. The IGF system plays a profound role in many …

TGFbeta is a multifunctional protein which affects many proteins taking part in cell cycle
regulation and, thanks to this, it influences cell growth and differentiation. TGFbeta can …

BACKGROUND: The effect of baohuoside-1 (B1), a novel flavonoid, on cell proliferation and
the cell cycle was evaluated in this study. METHODS: The antiproliferative properties of B1 …

Cellular distribution of the p27 (KIP1) protein and its phosphorylation on threonine (T) 187 in
mouse retinas from three stages of development, and retinoblastoma were examined …

Cyclin-dependent kinases (CDKs) are a family of evolutionarily conserved serine/threonine
kinases. CDK2 acts as a checkpoint for the G 1/S transition in the cell cycle. Despite a down …

We have identified and characterized a cyclin homolog from Bombyx mori
nucleopolyhedrovirus (BmNPV), encoding a 34kDa protein (ORF 120) with 48% homology …

Expression of the cdc2 gene is induced steeply at the G1-S-phase boundary. The previous
analysis of promoter elements that confer inducibility revealed the enhancer at positions-276 …