More than 500 million people worldwide are persistently infected with the hepatitis B virus
(HBV) and/or hepatitis C virus (HCV) and are at risk of developing chronic liver disease …

The hepatitis C virus (HCV) persists in the majority of infected individuals and is a significant
cause of human illness and death globally. Recent studies have yielded important insights …

The hepatitis B virus (HBV) and hepatitis C virus (HCV) are noncytopathic, hepatotropic
members of the hepadnavirus (HBV) and ffavivirus (HCV) families that cause acute and …

Chronic hepatitis C virus (HCV) infection is associated with impaired proliferative, cytokine,
and cytotoxic effector functions of HCV-specific CD8+ T cells that probably contribute …

Hepatitis C virus (HCV) infection frequently persists despite substantial virus-specific cellular
immune responses. To determine if immunologically driven sequence variation occurs with …

The recent discovery of natural immunity to the hepatitis C virus and vaccine efficacy in the
chimpanzee challenge model has allowed optimism about the development of at least a …

The basis of chronic infection following exposure to hepatitis C virus (HCV) infection is
unexplained. One factor may be the low frequency and immature phenotype of virus-specific …

We comprehensively studied the cellular immune response during acute human hepatitis C
virus (HCV) infection by monthly prospective sampling of persons at high risk of infection. In …

Lymphocyte recruitment to the liver is critical for viral clearance in acute hepatitis and in the
pathogenesis of chronic inflammatory liver disease when persistent chronic inflammation …

Hepatitis C virus (HCV) becomes persistent in the majority of infected individuals. In doing
so, the virus evades host adaptive immune responses, although the mechanisms …