Oxidative enzymopathies and vascular disease
JA Leopold, J Loscalzo - Arteriosclerosis, thrombosis, and vascular …, 2005 - Am Heart Assoc
In the vasculature, reactive oxygen species (ROS) generated by both mitochondrial
respiration and enzymatic sources serve as integral components of cellular signaling and …
respiration and enzymatic sources serve as integral components of cellular signaling and …
Impact of CYP2C9 genotype on pharmacokinetics: are all cyclooxygenase inhibitors the same?
AD Rodrigues - Drug Metabolism and Disposition, 2005 - ASPET
The market withdrawals of rofecoxib (Vioxx) and valdecoxib (Bextra) have focused
considerable attention on the side effect profiles of cyclooxygenase (COX) inhibitors. As a …
considerable attention on the side effect profiles of cyclooxygenase (COX) inhibitors. As a …
Identification of functional genetic variants in cyclooxygenase-2 and their association with risk of esophageal cancer
Background & Aims: Overexpression of cyclooxygenase-2 (COX-2) is implicated in many
steps of cancer development. Single nucleotide polymorphisms (SNPs) in the COX-2 …
steps of cancer development. Single nucleotide polymorphisms (SNPs) in the COX-2 …
Biological assessment of aspirin efficacy on healthy individuals: heterogeneous response or aspirin failure?
Background and Purpose—The widespread use of aspirin requires clarification of the
aspirin resistance phenomenon. Most studies on this field are focused on patients which …
aspirin resistance phenomenon. Most studies on this field are focused on patients which …
Cardiovascular complications of non-steroidal anti-inflammatory drugs
E Fosslien - Annals of Clinical & Laboratory Science, 2005 - Assoc Clin Scientists
Coxibs, such as rofecoxib, celecoxib, and valdecoxib, selectively inhibit cyclooxygenase
(COX)-2, the mainly inducible, pro-inflammatory COX isoform. Unlike traditional non …
(COX)-2, the mainly inducible, pro-inflammatory COX isoform. Unlike traditional non …
Genetic association studies in stroke: methodological issues and proposed standard criteria
M Dichgans, HS Markus - Stroke, 2005 - Am Heart Assoc
Background and Purpose—A large number of candidate gene association studies have
attempted to identify genes implicated in stroke, but there have been few replicable and …
attempted to identify genes implicated in stroke, but there have been few replicable and …
Contrasting effects of cyclooxygenase-1 (COX-1) and COX-2 deficiency on the host response to influenza A viral infection
MA Carey, JA Bradbury, JM Seubert… - The Journal of …, 2005 - journals.aai.org
Influenza is a significant cause of morbidity and mortality worldwide despite extensive
research and vaccine availability. The cyclooxygenase (COX) pathway is important in …
research and vaccine availability. The cyclooxygenase (COX) pathway is important in …
Cyclooxygenase-2 promotes early atherosclerotic lesion formation in ApoE-deficient and C57BL/6 mice
Cyclooxygenase (COX) 2 is expressed in atherosclerotic lesions. We have previously
reported that selective inhibition of COX-2 reduces early atherosclerosis in LDLR deficient …
reported that selective inhibition of COX-2 reduces early atherosclerosis in LDLR deficient …
PTGS2 (COX-2) −765G > C Promoter Variant Reduces Risk of Colorectal Adenoma among Nonusers of Nonsteroidal Anti-inflammatory Drugs
Abstract Prostaglandin H synthase 2 (PTGS2) or cyclooxygenase-2 (COX-2) has been
shown to play a key role in the regulation of inflammation, and its inhibition is associated …
shown to play a key role in the regulation of inflammation, and its inhibition is associated …
Priorities and standards in pharmacogenetic research
AC Need, AG Motulsky, DB Goldstein - Nature genetics, 2005 - nature.com
The current enthusiasm for pharmacogenetics draws much of its inspiration from the
relatively few examples of polymorphisms that have marked and seemingly clinically …
relatively few examples of polymorphisms that have marked and seemingly clinically …