Adenosine and brain function

BB Fredholm, JF Chen, RA Cunha… - Int Rev …, 2005 - books.google.com
A. Cellular and Subcellular Localization B. Pharmacological Tools to Study Adenosine
Receptors C. Signaling Via Adenosine Receptors D. Regulation of Receptor Expression and …

Neuroprotection by adenosine in the brain: From A1 receptor activation to A2A receptor blockade

RA Cunha - Purinergic signalling, 2005 - Springer
Adenosine is a neuromodulator that operates via the most abundant inhibitory adenosine A
1 receptors (A 1 Rs) and the less abundant, but widespread, facilitatory A 2A Rs. It is …

Adenosine A2A and dopamine D2 heteromeric receptor complexes and their function

K Fuxe, S Ferré, M Canals, M Torvinen… - Journal of molecular …, 2005 - Springer
The existence of A 2A-D 2 heteromeric complexes is based on coimmunoprecipitation
studies and on fluorescence resonance energy transfer and bioluminescence resonance …

Therapeutic potential of adenosine A2A receptor antagonists in Parkinson's disease

K Xu, E Bastia, M Schwarzschild - Pharmacology & therapeutics, 2005 - Elsevier
In the pursuit of improved treatments for Parkinson's disease (PD), the adenosine A2A
receptor has emerged as an attractive nondopaminergic target. Based on the compelling …

Different synaptic and subsynaptic localization of adenosine A2A receptors in the hippocampus and striatum of the rat

N Rebola, PM Canas, CR Oliveira, RA Cunha - Neuroscience, 2005 - Elsevier
Adenosine A2A receptors are most abundant in the striatum where they control the
striatopallidal pathway thus controlling locomotion. Extra-striatal A2A receptors are …

Co‐localization and functional interaction between adenosine A2A and metabotropic group 5 receptors in glutamatergic nerve terminals of the rat striatum

RJ Rodrigues, TM Alfaro, N Rebola… - Journal of …, 2005 - Wiley Online Library
The anti‐Parkinsonian effect of glutamate metabotropic group 5 (mGluR5) and adenosine
A2A receptor antagonists is believed to result from their ability to postsynaptically control the …

Animal models for the study of adenosine receptor function

R Yaar, MR Jones, JF Chen… - Journal of cellular …, 2005 - Wiley Online Library
Adenosine receptors represent a family of G‐protein coupled receptors that are ubiquitously
expressed in a wide variety of tissues. This family contains four receptor subtypes: A1 and …

New therapies for the treatment of Parkinson's disease: adenosine A2A receptor antagonists

A Pinna, J Wardas, N Simola, M Morelli - Life sciences, 2005 - Elsevier
The development of non-dopaminergic therapies for the treatment of Parkinson's disease
(PD) has attracted much interest in recent years. Among new different classes of drugs …

Coexpression of vesicular glutamate transporter‐3 and γ‐aminobutyric acidergic markers in rat rostral medullary raphe and intermediolateral cell column

RL Stornetta, DL Rosin, JR Simmons… - Journal of …, 2005 - Wiley Online Library
Markers of serotonergic, γ‐aminobutyric acid (GABA)‐ergic (glutamic acid decarboxylase,
67 kDa isoform; GAD‐67), and glutamatergic transmission (vesicular glutamate transporter …

The protective effect of adenosine A2A receptor antagonism in cerebral ischemia

F Pedata, M Gianfriddo, D Turchi, A Melani - Neurological research, 2005 - Taylor & Francis
Objectives: We reviewed our most recent work on the protective effect of adenosine
A2Aantagonism in cerebral ischemia. Methods: Focal ischemia was produced in rats by …