There are three connected molecular mechanisms of epigenetic cellular memory in
mammalian cells: DNA methylation, histone modifications, and RNA interference. The first …

Abstract The BRAF V600E mutation has been associated with microsatellite instability and
the CpG island methylator phenotype (CIMP) in colon cancer. We evaluated a large …

Background & Aims: The concept of a CpG island methylator phenotype (CIMP), especially
in microsatellite stable colon cancer, is not accepted universally. We therefore evaluated a …

Aims: To characterize a series of colorectal polyps, focusing on the clinicopathological
features of serrated adenoma (SA), mixed polyp (MP) and the recently recognized sessile …

ContextSignificant proportions of patients with hamartomatous polyposis or with
hyperplastic/mixed polyposis remain without specific clinical and molecular diagnosis or …

Cancers develop through a process called genomic instability, which generates diversity,
from which clonal evolution may occur. In colorectal cancers, this process has been …

Purpose: Hereditary nonpolyposis colorectal cancer (HNPCC) is the commonest form of
inherited colorectal cancer. Whereas it has been known that mismatch repair gene …

Patients with hyperplastic polyposis have multiple hyperplastic polyps (HPs) and increased
risk of colorectal carcinomas. Aberrant crypt foci (ACF) are postulated to be the earliest …

Background & Aims: Recently, an alternative pathway of tumorigenesis has been identified
in the colorectum associated with serrated precursor lesions, variable levels of microsatellite …

Abstract The Raf/MEK/ERK (MAPK) signal transduction cascade is an important mediator of
a number of cellular fates including growth, proliferation and survival. The BRAF gene is …