The endogenous cannabinoid system is an ubiquitous lipid signalling system that appeared
early in evolution and which has important regulatory functions throughout the body in all …

The brain's reward circuitry consists of an “in series” circuit of dopaminergic (DA) neurons in
the ventral tegmental area (VTA), nucleus accumbens (Acb), and that portion of the medial …

The CB 1 cannabinoid receptor is widely distributed in the central and peripheral nervous
system. Within the neuron, the CB 1 receptor is often localised in axon terminals, and its …

The paraventricular nucleus of the hypothalamus is an integration centre between the
central and peripheral autonomic nervous systems. It is involved in numerous functions from …

Increasing evidence indicates that bioactive lipids participate in the regulation of synaptic
function and dysfunction. We have demonstrated that signaling mediated by platelet …

Cannabinoids, such as the Δ9-tetrahydrocannabinol (THC), present in the cannabis plant,
as well as anandamide and 2-arachidonoyl glycerol, produced by the mammalian body …

Exogenously administered cannabinoids are neuroprotective in several different cellular
and animal models. In the current study, two cannabinoid CB1 receptor ligands (WIN 55,212 …

Cannabinoid agonists modulate a variety of behavioral functions by activating cannabinoid
receptors that are widely distributed throughout the central nervous system. In the present …

Septohippocampal cholinergic neurons play key roles in learning and memory processes,
and in the generation of hippocampal theta rhythm. The range of receptors for endogenous …

Since the discovery that cannabinoids exert biological actions through binding to specific
receptors, signal mechanisms triggered by these receptors have been focus of extensive …