The bacterial injection kit: type III secretion systems

LJ Mota, GR Cornelis - Annals of medicine, 2005 - Taylor & Francis
Type III secretion (T3S) systems are widespread among Gram‐negative bacteria pathogenic
for animals and plants, including Yersinia spp., Salmonella spp., Shigella spp …

Role of the Type III Secreted Exoenzymes S, T, and Y in Systemic Spread of Pseudomonas aeruginosa PAO1 In Vivo

RE Vance, A Rietsch, JJ Mekalanos - Infection and immunity, 2005 - Am Soc Microbiol
Pseudomonas aeruginosa uses a dedicated type III secretion system to deliver toxins
directly into the cytoplasm of host cells. While progress has been made in elucidating the …

The Phosphoinositol-3-Kinase–Protein Kinase B/Akt Pathway Is Critical for Pseudomonas aeruginosa Strain PAK Internalization

A Kierbel, A Gassama-Diagne, K Mostov… - Molecular biology of …, 2005 - Am Soc Cell Biol
Several Pseudomonas aeruginosa strains are internalized by epithelial cells in vitro and in
vivo, but the host pathways usurped by the bacteria to enter nonphagocytic cells are not …

Actin cytoskeleton disruption by ExoY and its effects on Pseudomonas aeruginosa invasion

BA Cowell, DJ Evans, SMJ Fleiszig - FEMS microbiology letters, 2005 - academic.oup.com
Three of the Type III-secreted effectors of Pseudomonas aeruginosa (ExoS, ExoT, and ExoY)
each alter mammalian cell morphology in culture without causing a loss of cell viability. For …

[HTML][HTML] Mutation of retS, encoding a putative hybrid two-component regulatory protein in Pseudomonas aeruginosa, attenuates multiple virulence mechanisms

I Zolfaghar, AA Angus, PJ Kang, A To, DJ Evans… - Microbes and …, 2005 - Elsevier
Two-component regulatory systems play an important role in bacterial virulence. We report
that mutation of a Pseudomonas aeruginosa gene designated retS (previously designated …

Uncoupling Crk signal transduction by Pseudomonas exoenzyme T

Q Deng, J Sun, JT Barbieri - Journal of Biological Chemistry, 2005 - ASBMB
Exoenzyme T (ExoT) is a bifunctional type III cytotoxin of Pseudomonas aeruginosa that
possesses both Rho GTPase-activating protein and ADP-ribosyltransferase activities. The …

An indirect enzyme-linked immunosorbent assay for rapid and quantitative assessment of Type III virulence phenotypes of Pseudomonas aeruginosa isolates

L Li, M Ledizet, K Kar, RA Koski… - Annals of Clinical …, 2005 - Springer
Background The presence of a Type III secretion system in clinical isolates of Pseudomonas
aeruginosa is associated with severe disease and poor outcomes in infections caused by …

The Type III Cytotoxins of Yersinia and Pseudomonas aeruginosa That Modulate the Actin Cytoskeleton

MR Baldwin, JT Barbieri - Bacterial Virulence Factors and Rho GTPases, 2005 - Springer
Initial studies of how bacterial toxins modulate the actin cytoskeleton have focused primarily
on the mode of action of these toxins. More recently, studies have addressed the molecular …

Role of the host cell in the type III translocation of Pseudomonas aeruginosa exoenzyme S

EA Rucks - 2005 - researchrepository.wvu.edu
Exoenzyme S (ExoS) is a bifunctional toxin that is directly translocated into eukaryotic cells
by the Pseudomonas aeruginosa (Pa) type III secretory (T3S) process. The N-terminal …

Type III secretion and the innate immune response in acute Pseudomonas aeruginosa pneumonia

CM Shaver - 2005 - search.proquest.com
Pseudomonas aeruginosa is a Gram-negative bacterium that causes severe hospital-
acquired pneumonia as well as several other serious illnesses. One major virulence …