We assessed the efficacy and safety of 10-d monotherapy with the orally administered
CCR5 antagonist maraviroc in 63 HIV-1-positive individuals prescreened for the absence of …

Objective We wished to characterize the epidemiological and clinical correlates of CXCR4-
using human immunodeficiency virus type 1 (HIV-1)(“X4 variants”) in a cross-sectional …

One of the key factors in developing improved medicines lies in understanding the
molecular basis of the complex diseases we treat. Investigation of genetic associations with …

Chemokine receptor genetic mutations are among the factors which have been shown to
influence human susceptibility to HIV-1 infection and progression. The CCR2-64I mutation …

Genetic polymorphisms in human genes can influence the risk for HIV-1 infection and
disease progression, although the reported effects of these alleles have been inconsistent …

Method of diagnosing and/or prognosticating HIV infection in a Subject comprising the steps
of:(a) performing in vitro a measurement of the level of a marker in the form of (i) urokinase …

Le varianti dei geni CCR5 e CCR2 sono state messe in relazione con una differente
suscettibilità all'infezione da HIV-1. In particolare, gli individui omozigoti per il CCR5-A32 …

El ARN de interferencia (ARNi) es una conservada respuesta biológica a la presencia de
ARN de doble cadena, lo cual origina el silenciamiento específico de secuencia de un gen …

ABSTRACT ARN interference (RNAi) is a conserved biological response to double-stranded
RNA that results in the sequence-specific silencing of target gene expression. Over the past …