ContextThe efficient sequestration of hemoglobin by the red blood cell membrane and the
presence of multiple hemoglobin clearance mechanisms suggest a critical need to prevent …

Reactive oxygen species (ROS) may contribute to tissue damage in many
pathophysiological conditions and participate in physiological signaling processes. The …

Abstract The synthetic triterpenoid 2-cyano-3, 12-dioxooleana-1, 9 (11)-dien-28-oic acid
(CDDO) and its derivative 1-[2-cyano-3-, 12-dioxooleana-1, 9 (11)-dien-28-oyl] imidazole …

Heme oxygenase (HO)-1, involved in the heme degradation process, is an important
antioxidant enzyme. The induction of HO-1 gene expression, in response to diverse …

Over the past decade, a great deal of interest and attention has been directed toward a
population of regulatory T cells (Treg) coexpressing the markers CD4 and CD25. The …

Pre-eclampsia is a hypertensive disorder of pregnancy characterized by shallow
placentation, inadequate placental perfusion, localized placental oxidative stress, a …

Carbon monoxide (CO), produced endogenously during heme degradation, is considered a
messenger molecule in vascular and neurologic tissues. To study this role, it is important to …

Heme oxygenase-1 (HO-1) is a key cytoprotective enzyme and an established marker of
oxidative stress. Increased HO-1 expression has been found in the resident macrophages in …

The enzyme heme oxygenase (HO) has been implicated in several physiological functions
throughout the body including control of vascular tone and regulation of the inflammatory …

Flavonoids including the aglycones, hesperetin (HT; 5, 7, 3′‐trihydroxy‐4′‐methoxy‐
flavanone), and naringenin (NE; 5, 7, 4′‐trihydroxy flavanone) and glycones, hesperidin …