In recent years, the list of tumor suppressor genes (or candidate TSG) that are inactivated
frequently by epigenetic events rather than classic mutation/deletion events has been …

Loss of heterozygosity of the small arm of chromosome 3 is one of the most common
alterations in human cancer. Most notably, a segment in 3p21. 3 is frequently lost in lung …

This 2004 volume in the World Health Organization series on histologic and genetic typing
of human tumors covers tumors of the kidney, urinary system, prostate, testis and …

The human Ras association domain family 1 (RASSF1) gene is located at 3p21. 3 in an area
that is believed to harbor at least one important tumor suppressor gene. The two major …

Introduction: The tumor suppressor genes RASSF1A, APC, H-cadherin, RARβ2, and cyclin
D2 are methylated more frequently in breast cancer than in adjacent benign tissue …

Loss of heterozygosity of a segment at 3p21. 3 is frequently observed in lung cancer and
several other carcinomas. We have identified the Ras-association domain family 1A gene …

Epigenetic inactivation of the RASSF1A tumor suppressor by CpG island methylation was
frequently detected in cancer. However, the mechanisms of this aberrant DNA methylation …

Aberrant DNA hypermethylation is a frequent finding in tumor cells, which has suggested
that inhibition of DNA methylation may be an effective cancer treatment strategy. Because …

Abstract Introduction Desmocollin 3 (DSC3) is a member of the cadherin superfamily of
calcium-dependent cell adhesion molecules and a principle component of desmosomes …

We analyzed RASSF1A and NORE1A methylation and BRAF mutation in 89 thyroid tumors,
42 non-neoplastic thyroid tissues and three thyroid tumor cell lines using polymerase chain …