Trauma is a serious global health problem, accounting for approximately one in 10 deaths
worldwide. Uncontrollable bleeding accounts for 39% of trauma-related deaths and is the …

Anemia and allogenic RBC transfusions are exceedingly common among critically ill
patients. Multiple pathologic mechanisms contribute to the genesis of anemia in these …

Background: Uncontrolled bleeding is a leading cause of death in trauma. Two randomized,
placebo-controlled, double-blind trials (one in blunt trauma and one in penetrating trauma) …

There has been a change in vernacular with respect to infections relating to surgical
procedures, owing to confusion between infections of surgical incisions and those of …

Background: Management strategies for blunt solid viscus injuries often include blood
transfusion. However, transfusion has previously been identified as an independent …

Background: Prior studies have suggested that blood transfusion (Tx) is associated with
infectious and respiratory complications in trauma patients. However, these studies are …

Provides an author's comments regarding the discussion of the clinical effects of transfusion
immunomodulation. Association of blood transfusion with an increased risk of post-operative …

Study objective To examine the relationship between packed RBC (pRBC) transfusion and
the development of ICU-acquired bloodstream infections (BSIs) Design Secondary analysis …

The purpose of this study was to determine if the quantity and age of blood is an
independent risk factor for in-hospital mortality, need for intensive care unit (ICU) care, and …

Background: During bacterial infection, pathogen and host compete for iron (Fe). The
inflammatory response associated with infection shifts Fe from the circulation into storage …