The central problem in the treatment of cocaine and heroin addiction is high rates of relapse
to drug use after periods of forced or self-imposed abstinence. Relapse can be modeled in …

The transition from casual drug use to addiction, and the intense drug craving that
accompanies it, has been postulated to result from neuroadaptations within the limbic …

The present study tested the hypothesis that separate neural substrates mediate cocaine
relapse elicited by drug-associated contextual stimuli vs explicit conditioned stimuli (CSs) …

Cocaine addiction in human addicts is characterized by a high rate of relapse following
successful detoxification. Relapse to drug taking/seeking can be precipitated by several …

The National Institute on Drug Abuse has funded a medications program that has
concentrated on the development of medications for opiate and cocaine dependence …

Glutamatergic neurotransmission has been suggested to modulate cue-induced drug-
seeking behavior. Here we examined the effects of metabotropic glutamate receptor …

The present paper proposes a model for the identification and the validation of brain
processes and mechanisms underlying smokers' cue reactivity. Smoking behaviour is …

Research is beginning to outline a role for the endocannabinoid system in cocaine
addiction. Human and animal studies indicate that exogenous cannabinoids modulate the …

The return to drug seeking, even after prolonged periods of abstinence, is a defining feature
of cocaine addiction. The neural circuitry underlying relapse has been identified in …

Chronic cocaine and withdrawal induce significant alterations in nucleus accumbens (NAc)
glutamatergic function in humans and rodent models of cocaine addiction. Dysregulation of …