Predicting clinical severity in sickle cell anaemia

MH Steinberg - British journal of haematology, 2005 - Wiley Online Library
The ability to predict the phenotype of an individual with sickle cell anaemia would allow a
reliable prognosis and could guide therapeutic decision making. Some risk factors for …

Defining stroke risk in children with sickle cell anaemia

C Hoppe - British journal of haematology, 2005 - Wiley Online Library
Sickle cell anaemia (SCA) is the most common cause of childhood stroke, occurring with the
highest frequency before the age of 6 years. Despite the relative frequency of stroke in SCA …

[PDF][PDF] Sickle cell disease: a multigenic perspective of a single gene disorder

A Kutlar - Hematology, 2005 - Taylor & Francis
Half a century has elapsed since the elucidation of the molecular basis of the sickle
hemoglobin mutation in the mid 50s. Although significant progress has been made in our …

Bioinformatics: computers or clinicians for complex disease risk assessment?

C Hoppe - European journal of human genetics, 2005 - nature.com
Anew study in which Paola Se-bastiani and co-workers apply a computer-assisted method
to determine the combined effects of multiple candidate gene single nucleotide …