The TRIM/RBCC proteins are defined by the presence of the tripartite motif composed of a
RING domain, one or two B‐box motifs and a coiled‐coil region. These proteins are involved …

The c‐Jun N‐terminal kinases (JNKs) were originally identified by their ability to
phosphorylate c‐Jun in response to UV‐irradiation, but now are recognized as critical …

The epidermal growth factor receptor (EGFR) signaling pathway is one of the most important
pathways that regulate growth, survival, proliferation, and differentiation in mammalian cells …

Abstract Approximately 5% of the Arabidopsis (Arabidopsis thaliana) proteome is predicted
to be involved in the ubiquitination/26S proteasome pathway. The majority of these …

A subset of proteins targeted by the N-end rule pathway bear degradation signals called N-
degrons, whose determinants include destabilizing N-terminal residues. Our previous work …

The heart is a dynamic organ capable of significant architectural remodeling, cellular
adaptations, and molecular reprogramming following both physiologic and pathologic …

We recently reported that macrophages from aged mice produced less tumor necrosis factor
(TNF)-α following lipopolysaccharide (LPS) stimulation than macrophages from young …

In the present study, the human TEB4 is identified as a novel ER (endoplasmic reticulum)-
resident ubiquitin ligase. TEB4 has homologues in many species and has a number of …

Mutations in the autoimmune regulator (AIRE) protein are the causative factor in
development of the human disease autoimmune polyendocrinopathy‐candidiasis …

The mK3, K3, and K5 gene products from the γ2 group of γ‐herpesviruses are the founding
members of a family of membrane‐associated ubiquitin E3 ligases. As part of the viral …