Animal eyes with widely different anatomical designs have long been thought to arise
independently, multiple times during evolution. This view was challenged about a decade …

The homeodomain is a highly conserved DNA-binding motif that is found in numerous
transcription factors throughout a large variety of species from yeast to humans. These gene …

Background The PAX6 protein is a highly conserved transcriptional regulator that is
important for normal ocular and neural development. In humans, heterozygous mutations of …

Protein–DNA interactions play a central role in transcriptional regulation and other biological
processes. Investigating the mechanism of binding affinity and specificity in protein–DNA …

Haploinsufficiency of the short stature homeobox gene SHOX has been found in patients
with idiopathic short stature (ISS) and Leri‐Weill dyschondrosteosis (LWD). In addition to …

The transcription factor Pax6 is essential for the development of the eyes and the central
nervous system of vertebrates and invertebrates. Pax6 contains two DNA-binding domains; …

The effects of neurotransmitters depend on the receptors expressed on the target cells. In
Caenorhabditis elegans, there are two types of GABA receptors that elicit opposite effects …

Pax genes encode transcription factors that are critical regulators of key developmental
processes in evolutionarily diverse animal phyla. Here we report the first isolation of a Pax …

Pax6 is a member of the Pax family of transcription factors and is essential for eye
development. Pax6 has two DNA-binding domains: the paired domain and the …

This thesis involves analyses of 3 2-helices, α-helices and of the change in residual entropy
of a protein upon chemical modification. Part of the long-term goal of understanding the …