▪ Abstract Acetylation is a key posttranslational modification of many proteins responsible for
regulating critical intracellular pathways. Although histones are the most thoroughly studied …

Histones are small basic proteins that, by complexing wtih DNA, form the nucleosome core.
Repetitive units of this nucleosome led to the chromatin in which all the human genome is …

The hydroxamic acid (HAA) analogue pan-histone deacetylase (HDAC) inhibitors (HDIs)
LAQ824 and LBH589 have been shown to induce acetylation and inhibit the ATP binding …

Plants, marine organisms, and microorganisms have evolved complex chemical defense
and signaling systems that are designed to protect them from predators and provide other …

Histone deacetylase (HDAC) inhibitors are a new class of targeted anticancer agents.
Several HDAC inhibitors are in clinical trials and have shown significant activity against a …

Epigenetic regulation of gene expression is mediated through alterations in the DNA
methylation status, covalent modifications of core nucleosomal histones, rearrangement of …

Impaired histone acetylation was recognized to be involved in carcinogenesis. Furthermore,
histone deacetylase (HDAC) inhibitors induce differentiation of breast cancer cells and …

NF-κB activation is reciprocally regulated by RelA/p65 acetylation and deacetylation, which
are mediated by histone acetyltransferases (HATs) and deacetylases (HDACs). Here we …

The epigenome is defined by DNA methylation patterns and the associated post-
translational modifications of histones. This histone code determines the expression status …

Purpose: Histone deacetylase (HDAC) inhibitors, which modulate chromatin structure and
gene expression, represent a class of anticancer agents that hold particular potential as …