An enhanced Th2 immune response and the elaboration of cytokines such as IL-4, IL-13,
and IL-5 contribute to the induction of allergy and asthma. Interferon-γ, a Th1 cytokine, acts …

Substantial experimental evidence now supports the notion that allergic diseases are
characterised by a skewing of the immune system towards a T-helper cell type-2 (Th2) …

Genetic factors are known to strongly influence susceptibility to allergic inflammation. The
Th2 cytokine IL-13 is a central mediator of allergy and asthma, and common single …

Atopic dermatitis (AD) is a chronic pruritic skin disease affecting up to 15% of children in
industrialized countries. AD belongs to the group of allergic disorders that include food …

A reduced risk of primary malignant adult brain tumors is observed among people reporting
asthma, hay fever, and other allergic conditions; however, findings may be attributed to …

BACKGROUND: Asthma is a common respiratory disease caused by the interaction of
genetic susceptibility and exposure to various environmental factors. Passive smoke …

Mice with a targeted deletion of the T-bet gene exhibit spontaneous airway
hyperresponsiveness (AHR), airway inflammation, enhanced recovery of Th2 cytokines from …

Background Evolutionarily conserved sequences likely have biological function. Methods To
determine whether variation in conserved sequences in non-coding DNA contributes to risk …

Graves' disease (GD) is an autoimmune disorder with genetic predisposition. IL-13 is an
important mediator of antiinflammatory immune responses and is expressed in the thyroid …

Background. Minimal-change nephrotic syndrome (MCNS) has been associated with atopy.
As interleukin-13 (IL-13) has been implicated in the pathogenesis of MCNS, we postulated …