The treatment of cancer through the development of new therapies is one of the most
important challenges of our time. The decoding of the human genome has yielded important …

The vertebrate kinetochore is a complex structure that specifies the attachments between the
chromosomes and microtubules of the spindle and is thus essential for accurate …

Abstract Histone deacetylases (HDACs) 1 and 2 share a high degree of homology and
coexist within the same protein complexes. Despite their close association, each possesses …

Transcription factor GATA‐1 and its cofactor FOG‐1 coordinate erythroid cell maturation by
activating erythroid‐specific genes and repressing genes associated with the …

Transcriptional repression of methylated genes can be mediated by the methyl-CpG binding
protein MeCP2. Here we show that human Brahma (Brm), a catalytic component of the …

BCL11 genes play crucial roles in lymphopoiesis and have been associated with
hematopoietic malignancies. Specifically, disruption of the BCL11B (B-cell chronic …

Estrogen receptor α (ER) is an epigenetically regulated gene. Inhibitors of DNA
methyltransferases (DNMTs) and histone deacetylases (HDACs) synergistically activate the …

Inflammatory lung diseases are characterised by increased expression of multiple
inflammatory genes that are regulated by proinflammatory transcription factors, such as NF-κ …

Vitamin A derivatives plays a crucial role in embryonic development, as demonstrated by the
teratogenic effect of either an excess or a deficiency in vitamin A. Retinoid effects extend …

A long path, initiated more than 40 years ago, has led to a deeper understanding of the
complexity of gene regulation in eukaryotic genomes. In addition to genetic mechanisms, the …