Compelling epidemiologic and molecular data indicate that genes play a primary role in
determining who is at risk for developing multiple sclerosis (MS), how the disease …

Major advancements have been achieved in our ability to diagnose multiple sclerosis (MS)
and to commence treatment intervention with agents that can favorably affect the disease …

Mechanisms for observed associations within the major histocompatibility complex (MHC)
and autoimmune diseases including multiple sclerosis (MS) remain uncertain. Genotyping of …

Detailed studies of the natural history of untreated multiple sclerosis (MS) have been carried
out in London, Ontario, Canada, over the past generation. There are now some 25,000 …

The cause of multiple sclerosis (MS) is unknown, but it is widely believed to be an
autoimmune disease occurring in genetically susceptible individuals after exposure to as-yet …

Background: Primary progressive multiple sclerosis (PP-MS) differs from relapsing-remitting
or secondary progressive MS (RR/SP-MS) in ways suggesting differences in the pathogenic …

Background/aim: Competing levels of cytokines, either locally within the eye or systemically,
may influence the eventual outcome of ocular inflammation. Polymorphism in the promoter …

Researchers have long suspected that genetic susceptibility is shared among autoimmune
diseases. With the increased understanding of genetic risks and disease etiology, we are …

The major histocompatibility complex (MHC) regulates multiple sclerosis (MS) and its model
experimental autoimmune encephalomyelitis (EAE). We created four new intra-MHC …

Childhood multiple sclerosis (MS) is a rare demyelinating autoimmune disease with different
risk factors and clinical features than adult onset MS. Onset of MS is extremely uncommon in …