Little is known about how the genotypic and molecular abnormalities associated with
epithelial cancers actually contribute to the histological phenotypes observed in tumours in …

Metastasis, the spread of a tumor from its primary site to other parts of the body, continues to
be the most significant problem in the field of cancer. Patients who present with metastatic …

Breast cancer recurrence is a fundamental clinical manifestation of tumor progression and
represents the principal cause of death from this disease. Using a conditional transgenic …

Purpose Gefitinib and erlotinib are small molecules that selectively inhibit epidermal growth
factor receptor (EGFR) tyrosine kinase activity. When these drugs were introduced into the …

This review article provides an overview on the most recent advances on the role of ErbB
receptors and growth factors of the epidermal growth factor (EGF)-family of peptides in …

Temporally and spatially constrained Hedgehog (Hh) signaling regulates cyclic growth of
hair follicle epithelium while constitutive Hh signaling drives the development of basal cell …

The completion of the human genome sequence and the development of new techniques,
which allow the visualisation of comprehensive gene expression patterns, has led to the …

The serine/threonine kinase AKT and its downstream mediator mammalian target of
rapamycin (mTOR) are activated in lung adenocarcinoma, and clinical trials are under way …

Activation of Src kinase plays important roles in the development of many neoplasias. Most
of the previous Src studies focused on the deregulation of Src kinase activity. The …

The ovarian hormones, estrogen and progesterone, play a pivotal role in normal and
neoplastic development of the mammary gland. These hormones have a paradoxical role as …