The extracellular matrix (ECM) is critical for all aspects of vascular biology. In concert with
supporting cells, endothelial cells (ECs) assemble a laminin-rich basement membrane …

Intimal thickening, the accumulation of cells and extracellular matrix within the inner vessel
wall, is a physiological response to mechanical injury, increased wall stress, or chemical …

The growth of solid tumours proceeds through two distinct phases: the avascular and the
vascular phase. It is during the latter stage that the insidious process of cancer invasion of …

Cell organization is largely orchestrated by extracellular gradients of morphogenetic
proteins. VEGF, an essential factor for capillary formation, is stored in the extracellular …

Angiogenesis is the process by which new blood vessels are formed from preexisting
vasculature. It is an essential feature of the female reproductive cycle, embryonic …

Previous work has shown that endothelial cell (EC)-derived matrix metalloproteinases
(MMPs) regulate regression of capillary tubes in vitro in a plasmin-and MMP-1 dependent …

After cerebral ischemia, angiogenesis, by supplying for the deficient perfusion, may be a
beneficial process for limiting neuronal death and promoting tissue repair. In this study, we …

Extracellular proteolysis plays a key role in many pathophysiologic processes including
cancer, inflammatory diseases, and cardiovascular conditions such as atherosclerosis and …

Monocytes are recruited into tumors from the circulation along defined chemotactic gradients
and they then differentiate into tumor‐associated macrophages (TAMs). Recent evidence …

Mice homozygous for a null mutation of the integrin α9 subunit die 6–12 days after birth from
bilateral chylothoraces suggesting an underlying defect in lymphatic development. However …