Endothelial extracellular matrix: biosynthesis, remodeling, and functions during vascular morphogenesis and neovessel stabilization

GE Davis, DR Senger - Circulation research, 2005 - Am Heart Assoc
The extracellular matrix (ECM) is critical for all aspects of vascular biology. In concert with
supporting cells, endothelial cells (ECs) assemble a laminin-rich basement membrane …

Dual role of matrix metalloproteinases (matrixins) in intimal thickening and atherosclerotic plaque rupture

AC Newby - Physiological reviews, 2005 - journals.physiology.org
Intimal thickening, the accumulation of cells and extracellular matrix within the inner vessel
wall, is a physiological response to mechanical injury, increased wall stress, or chemical …

Mathematical modelling of cancer cell invasion of tissue: The role of the urokinase plasminogen activation system

MAJ Chaplain, G Lolas - … Models and Methods in Applied Sciences, 2005 - World Scientific
The growth of solid tumours proceeds through two distinct phases: the avascular and the
vascular phase. It is during the latter stage that the insidious process of cancer invasion of …

Synergy between interstitial flow and VEGF directs capillary morphogenesis in vitro through a gradient amplification mechanism

CLE Helm, ME Fleury, AH Zisch… - Proceedings of the …, 2005 - National Acad Sciences
Cell organization is largely orchestrated by extracellular gradients of morphogenetic
proteins. VEGF, an essential factor for capillary formation, is stored in the extracellular …

Metalloproteinases and their inhibitors in tumor angiogenesis

MM Handsley, DR Edwards - International Journal of Cancer, 2005 - Wiley Online Library
Angiogenesis is the process by which new blood vessels are formed from preexisting
vasculature. It is an essential feature of the female reproductive cycle, embryonic …

MMP-1 activation by serine proteases and MMP-10 induces human capillary tubular network collapse and regression in 3D collagen matrices

WB Saunders, KJ Bayless… - Journal of cell science, 2005 - journals.biologists.com
Previous work has shown that endothelial cell (EC)-derived matrix metalloproteinases
(MMPs) regulate regression of capillary tubes in vitro in a plasmin-and MMP-1 dependent …

VEGF-induced BBB permeability is associated with an MMP-9 activity increase in cerebral ischemia: both effects decreased by Ang-1

S Valable, J Montaner, A Bellail… - Journal of Cerebral …, 2005 - journals.sagepub.com
After cerebral ischemia, angiogenesis, by supplying for the deficient perfusion, may be a
beneficial process for limiting neuronal death and promoting tissue repair. In this study, we …

Extracellular proteases in atherosclerosis and restenosis

A Garcia-Touchard, TD Henry, G Sangiorgi… - … , and vascular biology, 2005 - Am Heart Assoc
Extracellular proteolysis plays a key role in many pathophysiologic processes including
cancer, inflammatory diseases, and cardiovascular conditions such as atherosclerosis and …

Macrophage migration and gene expression in response to tumor hypoxia

C Murdoch, CE Lewis - International journal of cancer, 2005 - Wiley Online Library
Monocytes are recruited into tumors from the circulation along defined chemotactic gradients
and they then differentiate into tumor‐associated macrophages (TAMs). Recent evidence …

The lymphangiogenic vascular endothelial growth factors VEGF-C and-D are ligands for the integrin α9β1

NE Vlahakis, BA Young, A Atakilit… - Journal of Biological …, 2005 - ASBMB
Mice homozygous for a null mutation of the integrin α9 subunit die 6–12 days after birth from
bilateral chylothoraces suggesting an underlying defect in lymphatic development. However …