Epigenetic changes such as DNA methylation act to regulate gene expression in normal
mammalian development. However, promoter hypermethylation also plays a major role in …

Early experience permanently alters behavior and physiology. These effects are, in part,
mediated by sustained alterations in gene expression in selected brain regions. The critical …

Cytosine methylation is required for mammalian development and is often perturbed in
human cancer. To determine how this epigenetic modification is distributed in the genomes …

DNA methylation, histone deacetylation, and methylation of histone H3 at lysine 9 are the
three best-characterized covalent modifications associated with a repressed chromatin state …

It is widely acknowledged that the nature of the maternal care a child receives can have long-
term repercussions, and that children raised in deprived environments can have severe …

Azacytidine-and 5-aza-deoxycytidine (5-aza-CdR)-mediated reactivation of tumor
suppressor genes silenced by promoter methylation has provided an alternate approach in …

DNA methylation is a major epigenetic factor that has been postulated to regulate cell
lineage differentiation. We report here that conditional gene deletion of the maintenance …

Objective To investigate whether the abnormal expression of matrix metalloproteinases
(MMPs) 3, 9, and 13 and ADAMTS‐4 by human osteoarthritic (OA) chondrocytes is …

Increased levels of pup licking/grooming and arched-back nursing by rat mothers over the
first week of life alter the epigenome at a glucocorticoid receptor gene promoter in the …

In all organisms, cell proliferation is orchestrated by coordinated patterns of gene
expression. Transcription results from the activity of the RNA polymerase machinery and …