IPP (isopentenyl diphosphate) and DMAPP (dimethylallyl diphosphate) serve as the
universal precursors for the biosynthesis of isoprenoids. Besides the well-known …

Malaria continues to be a major threat in the developing world, with> 1 million clinical
episodes and 3000 deaths every day. In the last century, malaria claimed between 150 and …

The key enzyme in the non-mevalonate pathway of isoprenoid biosynthesis, 1-deoxy-d-
xylulose 5-phosphate reductoisomerase (DXR) has been shown to be the target enzyme of …

In the malaria parasite Plasmodium falciparum isoprenoid precursors are synthesised inside
a plastid-like organelle (apicoplast) by the mevalonate independent 1-deoxy-d-xylulose-5 …

Fosmidomycin is effective against malaria, but it needs to be given for≥ 4 days when used
alone. We conducted a study of 50 children with Plasmodium falciparum malaria to evaluate …

We present structure− activity relationships for 43 inhibitors of 1-deoxyxylulose-5-phosphate
(DOXP)-reductoisomerase, derived from protein-based docking, ligand-based 3D QSAR …

Human diseases like malaria, toxoplasmosis or cryptosporidiosis are caused by intracellular
protozoan parasites of the phylum Apicomplexa and are still a major health problem …

Considerable work still needs to be done to understand more fully the basic processes
going on inside the non-photosynthetic plastid organelle of Plasmodium spp., the causative …

Determined efforts are being made to explore the non-photosynthetic plastid organelle of
Plasmodium falciparum as a target for drug development. Certain antibiotics that block …

Substituted 3-[2-(diethoxyphosphoryl) propyl] oxazolo [4, 5-b] pyridine-2 (3H)-ones were
obtained by functionalization at 6-position with various substituents (aryl, vinyl, carbonyl …