Parkinson's disease (PD) is a progressive neurodegenerative movement disorder that
results primarily from the death of dopaminergic neurons in the substantia nigra. Although …

Gene defects play a major role in the pathogenesis of degenerative disorders of the nervous
system. In fact, it has been the very knowledge gained from genetic studies that has allowed …

We performed a two-tiered, whole-genome association study of Parkinson disease (PD). For
tier 1, we individually genotyped 198,345 uniformly spaced and informative single …

Genetics of Parkinson's disease : Current Opinion in Neurology Genetics of Parkinson's
disease : Current Opinion in Neurology Log in or Register Subscribe to journalSubscribe Get …

Many studies have implicated phosphorylated tau in the Alzheimer disease process.
However, the cellular fate of phosphorylated tau has only recently been described. Recent …

It remains unclear whether genetic variants in SNCA (the alpha-synuclein gene) alter risk for
sporadic Parkinson's disease (PD). The polymorphic mixed sequence repeat (NACP-Rep1) …

We implicate a recently described form of mitochondrial mutation, mitochondrial
microheteroplasmy, as a candidate for the principal component of aging. Microheteroplasmy …

Major progress has been made in the last decade in understanding the genetic basis of PD
(Parkinson's disease) with five genes unequivocally associated with disease. As a result …

To avoid the possible confounding effect of population stratification, we employed a
discordant sibling study design and a liberalization of the sibling transmission disequilibrium …

Association studies are an increasingly popular way to test single nucleotide polymorphisms
and other gene sequence variations for their involvement in complex disease. Alzheimers …