The three main organs affected by metastasis of all cancers include lungs, liver, and bone.
Clinical confirmation of tumor spread to these organs is a negative prognostic sign that …

Practicing evidenced-based medicine some 25 centuries ago, Hippocrates proclaimed" Let
food be thy medicine and medicine be thy food." This advice parallels the common American …

Surgical ovariectomy and orchiectomy, first proposed over a century ago, are effective in
breast and prostate cancer therapy, respectively. Later, the discovery of steroid hormones …

Peroxisome proliferator-activated receptor gamma (PPARγ) plays a critical albeit poorly
defined role in the development and progression of several cancer types including those of …

Release of high levels of nitric oxide (NO) is associated with osteoblastic cell death. The
mechanisms of NO-induced cytotoxicity are not well documented and it is presently not …

The selective estrogen receptor modulator (SERM), tamoxifen, effectively slows the
progression of estrogen-positive breast cancer and aids in the prevention of cancer in at-risk …

Reciprocal interactions between tumor cells and endothelial cells constitute the most
important stage of tumor metastasis. There is growing evidence suggesting that β-estradiol …

Considering importance of developing selective estrogen receptor modulators (SERMs), the
present paper explores selectivity requirements of tetrahydroisoquinoline derivatives for …

In connection to developing non-steroidal estrogen analogs, the present study explores the
pharmacophore of triphenylacrylonitriles (Fig. 1) for binding affinity to estrogen receptor …

Our purpose was to identify tamoxifen (TAM) responsive genes after 30 days of TAM
treatment in tumor tissues obtained from women with breast cancer using microarray …