Stimuli-responsive polymers show a sharp change in properties upon a small or modest
change in environmental condition, eg temperature, light, salt concentration or pH. This …

Traditional screening paradigms often focus on single targets. To facilitate drug discovery in
the more complex physiological environment of a cell or organism, powerful cellular imaging …

A europium complex selectively staining the nucleolus of NIH 3T3, HeLa, and HDF cells is
reported. This complex possesses not only the advantage of the long lifetime of europium …

Traditional small-molecule fluorophores are always fluorescent. This attribute can obscure
valuable information in biological experiments. Here, we report on a versatile “latent” …

A number of neurodegenerative disorders may potentially be treated by the delivery of
therapeutic genes to neurons. Nonviral gene delivery systems, however, typically provide …

This review deals with the drug transporters allowing drugs to enter and leave cells by
carrier-mediated pathways. Emphasis is put on liver transporters but systems in gut, kidney …

Protein transduction domains such as those derived from the HIV protein TAT have great
potential as vectors for delivery of therapeutic entities such as genes and proteins into cells …

Background Synthetic vectors such as polymers have the potential to reduce the safety
problems associated with viral vectors; however, their low transfection efficiency limits their …

There is a vast number of bacterial and plant toxins that affect cytosolic targets in
mammalian cells, and whether the purpose of the toxin is to act as a defence mechanism …

This study was performed to evaluate insulin permeability across human bronchial epithelial
cell lines and investigate if insulin is transported via the paracellular or transcellular …