Human African trypanosomiasis, also known as sleeping sickness, is caused by protozoan
parasites of the genus Trypanosoma, and is a major cause of human mortality and morbidity …

Human African trypanosomiasis (HAT), or sleeping sickness, describes not one but two
discrete diseases: that caused by Trypanosoma brucei rhodesiense and that caused by T. b …

High systemic drug toxicity and increasing prevalence of drug resistance hampers efficient
treatment of human African trypanosomiasis (HAT). Hence, development of new highly …

Chemotherapy against human African trypanosomiasis relies on four drugs that cause
frequent and occasionally severe side‐effects. Because human African trypanosomiasis is a …

Abstract Human African Trypanosomiasis (HAT), which is also known as sleeping sickness,
is a major cause of death and disability in 36 countries in sub-Saharan Africa. The disease is …

Drugs can be targeted into African trypanosomes by exploiting carrier proteins at the surface
of these parasites. This has been clearly demonstrated in the case of the melamine-based …

Trypanosomosis is a major cause of mortality for dogs in Nigeria and treatment with
diminazene aceturate has steadily become less effective, either as a result of low quality of …

A novel trypanocide, 2, 5-bis (4-amidinophenyl) furan (DB75), in its prodrug amidoxime-
derivative form, 2, 5-bis (4-amidinophenyl) furan-bis-O-methylamidoxime (DB289), is in trials …

Objective To assess the operational feasibility of detecting human African trypanosomiasis
by active and passive case finding using the card agglutination test with serial dilution of …

OBJECTIVE: In 2002-03, the Republic of the Congo increased the threshold separating
stage 1 and 2 cases of human African trypanosomiasis (HAT) from a cerebrospinal fluid …