Purpose: The integrin αvβ3 plays a key role in angiogenesis and tumor cell metastasis and
is therefore an important target for new therapeutic and diagnostic strategies. We have …

Purpose: Integrins are expressed by numerous tumor types including breast cancer, in
which they play a crucial role in tumor growth and metastasis. In this study, we evaluated the …

Molecular interactions between RGD peptides and integrins are known to mediate many
biological and pathological processes. This has led to an increased interest in the …

Junctional adhesion molecule-A (JAM-A) is a member of the immunoglobulin superfamily,
and is mainly expressed in the tight junctions of both epithelial and endothelial cells. We …

Focal adhesion kinase (FAK) is phosphorylated on tyrosine and serine residues after cell
activation. In the present work, we investigated the relationship between tyrosine and serine …

The focus of this study was to gain insight into the role (s) of osteonectin in the preferential
metastasis of breast cancer cells to bone. Osteonectin was isolated from conditioned media …

The extracellular bone matrix protein bone sialoprotein (BSP) is considered to play an
important role in the pathogenesis of lytic skeletal lesions which are associated with severe …

Background and Objectives Integrins mediate the migration, adhesion and proliferation of
vascular smooth muscle cells. Adenosine diphosphate (ADP) can activate vascular …

ABSTRACT Background and Objectives: Integrins mediate the migration, adhesion and
proliferation of vascular smooth muscle cells. Adenosine diphosphate (ADP) can activate …

Bone sialoprotein (BSP) is an acidic glycoprotein that is normally expressed in mineralized
tissues and aberrantly expressed in metastatic osteotropic tumours. BSP belongs to the …