p53—A natural cancer killer: Structural insights and therapeutic concepts

L Römer, C Klein, A Dehner, H Kessler… - Angewandte Chemie …, 2006 - Wiley Online Library
Every single day, the DNA of each cell in the human body is mutated thousands of times,
even in absence of oncogenes or extreme radiation. Many of these mutations could lead to …

Chaperones in preventing protein denaturation in living cells and protecting against cellular stress

HH Kampinga - Molecular Chaperones in Health and Disease, 2006 - Springer
A variety of cellular internal and external stress conditions can be classified as proteotoxic
stresses. Proteotoxic stresses can be defined as stresses that increase the fraction of …

Activation of endoplasmic reticulum stress response during the development of ischemic heart disease

A Azfer, J Niu, LM Rogers… - American Journal …, 2006 - journals.physiology.org
Endoplasmic reticulum (ER) stress has been found to be associated with neurodegenerative
diseases and diabetes mellitus. Whether ER stress is involved in the development of heart …

The antioxidant protein alkylhydroperoxide reductase of Helicobacter pylori switches from a peroxide reductase to a molecular chaperone function

MH Chuang, MS Wu, WL Lo, JT Lin… - Proceedings of the …, 2006 - National Acad Sciences
Helicobacter pylori, an oxygen-sensitive microaerophilic bacterium, contains many
antioxidant proteins, among which alkylhydroperoxide reductase (AhpC) is the most …

System, method and apparatus for evaluating tissue temperature

PE Eggers, JL Ridihalgh, M Mayerchak… - US Patent …, 2006 - Google Patents
4,207,896 4,209,017 4.323, 056 4,364,377 4,364,390 4,369,345 4,520,249 4,545,368
4,574,782 4,690,130 4,695,713 4,798,215 4,807,620 4,846,196 4,869,247 4,979,518 …

Differential expression of three Paralichthys olivaceus Hsp40 genes in responses to virus infection and heat shock

CW Dong, YB Zhang, QY Zhang, JF Gui - Fish & shellfish immunology, 2006 - Elsevier
Heat shock proteins (Hsps) are a family of highly conserved cellular proteins present in all
organisms, mediating a range of essential housekeeping and cytoprotective functions as …

Therapy through chaperones: sense or antisense? Cystic fibrosis as a model disease

MD Amaral - Journal of inherited metabolic disease, 2006 - Wiley Online Library
Massive production and accumulation of a single abnormal protein may constitute a major
toxic burden for the cell and even compromise the organism's long‐term viability …

Chaperone-like activity of macrophage migration inhibitory factor

OA Cherepkova, EM Lyutova, TB Eronina… - The international journal …, 2006 - Elsevier
Macrophage migration inhibitory factor is a ubiquitous multifunctional cytokine having
diverse immunological and neuroendocrine properties. Although this protein is known to be …

Protein Expression Profiles of Chlamydia pneumoniae in Models of Persistence versus Those of Heat Shock Stress Response

S Mukhopadhyay, RD Miller, ED Sullivan… - Infection and …, 2006 - Am Soc Microbiol
Chlamydia pneumoniae is an obligate intracellular pathogen that causes both acute and
chronic human disease. Several in vitro models of chlamydial persistence have been …

Expression of and secretion through the Aeromonas salmonicida type III secretion system

RO Ebanks, LC Knickle, M Goguen, JM Boyd… - …, 2006 - microbiologyresearch.org
Aeromonas salmonicida subsp. salmonicida is the aetiological agent of furunculosis, a
disease of farmed and wild salmonids. The type III secretion system (TTSS) is one of the …