Circadian rhythms are∼ 24-h oscillations in behavior and physiology, which are internally
generated and function to anticipate the environmental changes associated with the solar …

There is a growing recognition that the circadian timing system, in particular recently
discovered clock genes, plays a major role in a wide range of physiological systems …

In mammals, the master clock of the suprachiasmatic nuclei (SCN) and subordinate clocks
found throughout the body coordinate circadian rhythms of behavior and physiology. We …

Circadian rhythms are essential to health. Their disruption is associated with metabolic
diseases in experimental animals and man [1–3]. Local metabolic rhythms represent an …

The Period2 gene, an indispensable component of the circadian clock, not only modulates
circadian oscillations, but also regulates organic function. We examined whether …

The three PERIOD proteins form a major negative feedback component of the molecular
mechanism governing the periodicity of the vertebrate circadian clock. Genetic variations …

Circadian clocks drive daily rhythms in virtually all organisms. In mammals, the
suprachiasmatic nucleus (SCN) is recognized as the master clock that synchronizes central …

Disruption of circadian rhythm is believed to play a critical role in cancer development. To
gain further insights into the roles of circadian genes in chronic myeloid leukemia (CML), we …

Circadian rhythms are generated by endogenous clocks in the central brain oscillator, the
suprachiasmatic nucleus, and peripheral tissues. The molecular basis for the circadian clock …

The molecular mechanism of circadian rhythmicity is usually modeled by a transcription/
translation feedback oscillator in which clock proteins negatively feed back on their own …