Abstract The cholinesterase inhibitors (ChE-Is) attenuate the cholinergic deficit underlying
the cognitive and neuropsychiatric dysfunctions in patients with AD. Inhibition of brain …

Covering: January 1980 to August 2005This review describes 183 compounds obtained
from plants and fungi which have been shown to inhibit acetylcholinesterase. The …

Acetylcholine is widely distributed in the nervous system and has been implicated to play a
critical role in cerebral cortical development, cortical activity, controlling cerebral blood flow …

Tacrine and melatonin are well-known drugs with activities as an acetylcholinesterase
(AChE) inhibitor and free radical scavenger, respectively. In this work, we report new hybrids …

Salvia officinalis (sage) has previously been shown both to possess in vitro cholinesterase
inhibiting properties, and to enhance mnemonic performance and improve mood in healthy …

The X-ray crystal structures were solved for complexes with Torpedo californica
acetylcholinesterase of two bivalent tacrine derivative compounds in which the two tacrine …

Current pharmacotherapy for Alzheimer's disease involves compounds that are aimed at
increasing the levels of acetylcholine in the brain by facilitating cholinergic …

A fundamental postulate in the classical drug design paradigm is that the effect of a drug in
the human body is a consequence of the molecular recognition between a ligand (the drug) …

The therapeutic use of enzyme inhibitors in treatment of neurodegenerative diseases has its
origin in the anti Parkinson action of the selective monoamine oxidase (MAO) B inhibitor, l …

The recent therapeutic approach in which drug candidates are designed to possess diverse
pharmacological properties and act on multiple targets has stimulated the development of …