VIP–PACAP system in immunity: new insights for multitarget therapy

RP Gomariz, Y Juarranz, C ABAD… - Annals of the New …, 2006 - Wiley Online Library
Our research about VIP/PACAP and the immune system goes back to 1990 when our group
described the expression of VIP on lymphocytes for the first time. Since this year, using three …

Roles of PACAP‐containing retinal ganglion cells in circadian timing

J Hannibal - International review of cytology, 2006 - Elsevier
The brain's biological clock located in the suprachiasmatic nucleus (SCN) generates
circadian rhythms in physiology and behavior. The clock‐driven rhythms need daily …

The neuropeptide PACAP promotes?‐secretase pathway for processing Alzheimer amyloid precursor protein

E Kojro, R Postina, C Buro, C Meiringer… - The FASEB …, 2006 - Wiley Online Library
The neuropeptide pituitary adenylate cyclase‐activating polypeptide (PACAP) has
neurotrophic as well as anti‐apoptotic properties and is involved in learning and memory …

The neurotrophic effects of PACAP in PC12 cells: control by multiple transduction pathways

A Ravni, S Bourgault, A Lebon, P Chan… - Journal of …, 2006 - Wiley Online Library
Pituitary adenylate cyclase‐activating polypeptide (PACAP) and vasoactive intestinal
polypeptide (VIP) are closely related members of the secretin superfamily of neuropeptides …

A novel cyclic AMP-dependent Epac-Rit signaling pathway contributes to PACAP38-mediated neuronal differentiation

GX Shi, H Rehmann, DA Andres - Molecular and cellular biology, 2006 - Taylor & Francis
Pituitary adenylate cyclase-activating polypeptide (PACAP38) stimulation results in the
activation of Gsα protein-coupled receptors to regulate neuronal differentiation in a cyclic …

Evolution of secretin family GPCR members in the metazoa

JCR Cardoso, VC Pinto, FA Vieira, MS Clark… - BMC evolutionary …, 2006 - Springer
Background Comparative approaches using protostome and deuterostome data have
greatly contributed to understanding gene function and organismal complexity. The family 2 …

Regulation of glutamatergic signalling by PACAP in the mammalian suprachiasmatic nucleus

S Michel, J Itri, JH Han, K Gniotczynski, CS Colwell - BMC neuroscience, 2006 - Springer
Background Previous studies indicate that light information reaches the suprachiasmatic
nucleus (SCN) through a subpopulation of retinal ganglion cells that contain both glutamate …

New insights into the central PACAPergic system from the phenotypes in PACAP‐and PACAP receptor‐knockout mice

H Hashimoto, N Shintani, A Baba - … of the New York Academy of …, 2006 - Wiley Online Library
Pituitary adenylate cyclase‐activating polypeptide (PACAP) is a structurally highly
conserved neuropeptide and displays pleiotropic activity, including functioning as a …

Characterization of novel splice variants of the PAC1 receptor in human neuroblastoma cells: consequences for signaling by VIP and PACAP

EM Lutz, E Ronaldson, P Shaw, MS Johnson… - Molecular and Cellular …, 2006 - Elsevier
Expression of VPAC and PAC1 receptor isoforms was determined in six neuroblastoma cell
lines as well as in human embryonic and adult brain using reverse transcriptase PCR and …

Neuropeptide binding reflects convergent and divergent evolution in species-typical group sizes

JL Goodson, AK Evans, Y Wang - Hormones and behavior, 2006 - Elsevier
Neuroendocrine factors that produce species differences in aggregation behavior
(“sociality”) are largely unknown, although relevant studies should yield important insights …