Chemical biology approaches have a long history in the exploration of the G‐protein‐
coupled receptor (GPCR) family, which represents the largest and most important group of …

Huey Lewis and the News summed it up nicely in their 1980s hit record:'I want a new drug,
one that won't make me sick, one that won't make me crash my car, or make me feel three …

Studies showing that neurotrophin binding to p75NTR can promote cell survival in the
absence of Trk (tropomyosin-related kinase) receptors, together with recent structural data …

In the human, chemokines represent a structurally related family of more than forty cytokines
which act on distinct subsets of leukocytes via specific G protein-coupled receptors …

Mechanisms of chemoattraction underlie the spatial organization of the cells of the immune
system under basal conditions and the localization of these cells to sites of inflammation …

Background and purpose: The chemokine receptor CCR1 is a potential target for the
treatment of rheumatoid arthritis. To explore the impact of CCR1 blockade in experimental …

Since the identification of the first chemotactic cytokines 20 years ago, the field has
mushroomed, with the discovery of approximately 40 ligands, which interact with 20 different …

Various cytokines play a critical role in pathophysiology of chronic inflammatory lung
diseases including asthma and chronic obstructive pulmonary disease (COPD). The …

A majority of small molecule non-peptide ligands for chemokine receptors in general are
characterized by the presence of one or two centrally located, positively charged nitrogen …

CC chemokine ligand 11 (CCL11/eotaxin) and other CC chemokine receptor 3 (CCR3)
ligands (CCL24/eotaxin-2, CCL26/eotaxin-3, CCL13/monocyte chemotactic protein-4, etc.) …