CD1d presentation of α-galactosyl ceramides to natural killer T cells has been a focal point
of the study of regulatory T cells. KRN7000, an α-galactosyl ceramide originally generated …

CD1-restricted T cells can be activated by diverse lipids derived from mammals, bacteria
and protozoa. Certain lipids function as antigens, which bind to CD1 proteins and contact T …

Glycolipid ligands for invariant natural killer T cells (i NKT cells) are loaded onto CD1d
molecules in the late endosome/lysosome. Accumulation of glycosphingolipids (GSLs) in …

Invariant human TCR Vα24-Jα18+/Vβ11+ NKT cells (iNKT) are restricted by CD1d–α-
glycosylceramides. We analyzed crystal structures and binding characteristics for an iNKT …

CD1 proteins have been conserved throughout mammalian evolution and function to
present lipid antigens to T cells. Crystal structures of CD1‐lipid complexes show that CD1 …

CD1d-restricted NKT cells play important regulatory roles in various immune responses and
are rapidly and selectively depleted upon infection with HIV-1. The cause of this selective …

Invariant NKT cells (iNKT cells) are characterized by a semi-invariant TCR comprising an
invariant α-chain paired with β-chains with limited BV gene usage which are specific for …

BACKGROUND/AIMS: Human invariant natural killer T (iNKT) cells express a TCR Vα24-
JαQ paired with Vβ11 and are activated by a surrogate ligand, α-galactosylceramide …

We tested two alternative oxidation strategies to produce conotoxins α-GI and μ-PIIIA. The
peptides were either reversibly immobilized on a solid support and then oxidized, or the …

Invariant natural killer T (iNKT) cells are a small but powerful subset of regulatory T cells
involved in the modulation of a variety of normal and pathological immune responses. In …