Lymph nodes that lie immediately downstream of tumors [tumor‐draining lymph nodes
(TDLNs)] undergo profound alterations due to the presence of the upstream tumor. The …

Cancer immunotherapy has been predominantly focused on biologically based intervention
strategies. However, recent advances in the understanding of tumour–host interactions at …

Dendritic cell (DC) tryptophan catabolism has emerged in recent years as a major
mechanism of peripheral tolerance. However, there are features of this mechanism, initiated …

In the last decade there has been an increasing interest for the action of regulatory T cells
(Treg) in preventing transplant rejection, autoimmunity and other inflammatory diseases and …

Breakdown of the essential amino acid tryptophan by indoleamine-2, 3-dioxygenase has
profound suppressive effects on T cell immunity. These immunosuppressive effects are in …

A law of Physics says that the mechanical work between two points depends on the chosen
path. Writing a thesis involves certainly some mechanical work and thus it obeys this law; it …

ABSTRACT Indoleamine 2, 3-dioxygenase (IDO) is a novel immunosuppressive agent
expressed in some subsets of normal and neoplastic cells, including acute myeloid …

Infection with the human immunodeficiency virus (HIV)-1 results in acute and progressive
numerical loss of CD4+ T helper cells and functional impairment of T cell responses. The …

Kidney transplantation is inevitably faced with overcoming the immune response to the
grafted organ, necessitating immunosuppressive therapy. Further, the immunogenicity of the …

The word 'privilege'implies a special status. The concept of immune privilege was coined in
the mid-20th century to describe observations that immunogenic tissues and tumors placed …